Petroleum-based adhesives are mainly used in industries such as automobiles, textiles, and packaging. However, interest in biomass-based materials is increasing to improve environmental problems caused by the excessive use of petroleum-based materials. This work focuses on novel poly(Isosorbide-co-1,4-cyclohexanedimethanol succinate-co-citrate) (PICSC) consisting of biomass monomers. Each of these component function as a thermal and adhesive property. The highest adhesion value was 4.5 MPa which is comparable to conventional hot melt. By controlling the molar ratio of monomers, various properties could be obtained. Owing to rigid intra-structure created by citric acid and isosorbide, high mechanical properties were obtained while flexible properties of 1,4-cyclohexanedimethanol and succinic acid contributed to easy wetting. Furthermore, degradation properties were analyzed through enzymatic degradation experiment.