Predominant Factor to Influence Cellular Behavior on Electrospun Nanofibrous Scaffolds. Wettability or Surface Morphology?
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초록
내용
In the present work, we have prepared two sets of polycaprolactone (PCL) based electrospun nanofibrous scaffolds, viz. surface morphology altered PCL scaffold (SMA PCL) with different surface morphology (P90, P80, and P70) and hydrophilic PCL-chitosan scaffold with different chitosan content (PC-a, PC-b, and PC-c). We further investigated the scaffolds' cell attachment and cell proliferation ability to find out which is a predominant factor, wettability, or surface morphology? From the results, we conclude that increasing the wettable property of a nanofibrous scaffold has been more influential in directing cellular behavior than surface morphology modification in the scaffold.