Photon Upconverting Hyaluronate Nanoparticles for Transdermal Delivery System
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초록
내용
Short-wavelength light has been widely used in photomedicine owing to its higher energy than long-wavelength light. However, this light has limitations such as low penetration into tissue and cell damage. To resolve these drawbacks, we developed photon upconverting hyaluronate nanoparticles (UC HA-PCL NPs), converting lower energy photons into higher energy photon. UC HA-PCL NPs that steady emit blue light was composed of PdTPBP as sensitizer and perylene as acceptor. Using DLS and TEM, we could confirm the successful preparation of spherical UC HA-PCL NPs with narrow size distribution and the stability of NPs. In addition, in the skin penetration test, we could confirm that the UC HA-PCL NPs successfully penetrated porcine skin and emitted upconverted light. Taken together, our HA NPs are feasible for photomedicine and can overcome the barriers of short-wavelength light with low transmittance.