MMP-responsive auto-clicked gold nanoparticles for tumor targeting
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초록
내용
To manipulate size-inspired retention and clearance of nanoparticles, we herein designed a matrix metalloproteinase (MMP)-responsive nanoparticle clusters with high fidelity of size changes. AuNPs were surface-incorporated with doxorubicin by polymerization of dopamine. The incorporation of PDA-assisted doxorubicin was characterized by dynamic light scattering, electron microscopy, and spectroscopy. These nanoparticles (Dox-PDA@AuNPs) were separately decorated with 1) dibenzocyclooctyne (DBCO) moieties and 2) azido moieties and MMP-responsive PEG chains. It is anticipated that this methoxy PEG shell is peeled off when the particles reach MMP-rich environment such as aggressive solid tumors. This in turn displays the azido moieties to another Dox-PDA@AuNPs with DBCO moieties and ultimately leads to copper-free clicking of two different particles. These nanoclusters are highly retained in tumor tissues, thereby enhancing the efficacy of the combined chemo-photothermal therapy.