Enzymatic Fabrication of NIR-responsive Polycatecholic Pigment in a Site-specific Manner
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Melanin is a biopigment that exhibits multifunctionality, such as protection against ultraviolet radiation, radical scavenging, and thermal regulation through near-infrared light to heat conversion. Interestingly, the representative of artificial melanin, polydopamine, has received great attention as an adhesive used for surface coatings. However, the site-specific fabrication of polydopamine requires complicated procedures, extremely laborious and time consuming. Herein, we developed a simple site-specific fabrication method of polycatecholamine pigment by utilizing its adhesive property to horseradish peroxidase, a biocatalyst that initiates catechol oxidation. The pigment was successfully fabricated with high resolution and showed good biocompatibility. In addition, the pigment possessed a high photothermal conversion efficiency enough to induce local cancer cell killing on pigmented area.