Novel Synthesis of Water-Soluble PPE Polymers and Their Potential Use
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In the past few years, researchers have put immense interest in effective sensing, imaging, and therapeutic strategies for the treatment of diseases by quick and accurate diagnosis. Among the various available techniques for sensing and imaging, the strategies based on fluorescence exhibit noticeable advantages and offer distinctive opportunities. Structurally improved conjugated polymers with hydrophilic and functional pendant substituents have shown great potential applications in many fields including fluorescence sensors due to their high sensitivity and selectivity of detection measurement. However, most reported conjugated polymers do not have appreciable aqueous solubility and functional moieties for sensing and delivery. Therefore, we have designed and synthesized a water-soluble conjugated polymer, poly(para-phenyleneethynylene), by the polymerization of Monomer 1 and Monomer 2 via Pd-catalyzed Sonogashira coupling reaction.