Rapidly-curable surgical glues enforced by adjustable multilength networks
발표자
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초록
내용
Recently, surgical adhesives are used in various medical fields as a promising potential for sutureless wound closures. Nevertheless, existing limitations of conventional medical glues including variable adhesions in wet conditions, improper mechanical properties, and toxicity hindered its application on ocular surface. In this study, we developed photocrosslinkable hyaluronic acid (HA) with multilength networks enabling adjustment of properties. Mechanical and adhesive properties were adjusted by introducing short and long crosslinkable groups. In the in vivo test, the HA glue sealed the wound area within 5 seconds and exhibited enhanced healing efficiency by a firm water-tight seal compared to the control without compromising safety issues (low-energy curing light) and transparency.