Synthesis of Polyethers with Carboxylic Acid Pendant Group via Anionic Ring-Opening Polymerization
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초록
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Polymers with carboxylic acid are useful in many fields such as drug delivery and adhesion. Unlike common radical polymerization, it is difficult to synthesize polymers with carboxylic acid via anionic ring opening polymerization, due to harsh reaction conditions. While a carboxylic acid functionalized polyether, poly(glycidoxy acetic acid) was prepared in our previous research using monomer-activated ring-opening polymerization without side reaction, it suffered from low initiation efficiency. Here, we present a novel functional monomer with oxazoline protecting group to synthesize PGA in controllable manner. Stepwise synthesis of the monomer and polymers was carefully analysed via 1H-NMR, GPC, and MALDI-ToF/ToF. After deprotection, desired PGA polymers were obtained. Furthermore, copolymerization with other monomers and a macroinitiator yielded well-defined polymers. We anticipate this study will provide a new platform for polyether synthesis, with functional carboxylic acid groups.