Design of Iodinated Polymeric Nanoparticle as CT Contrast Agents with Biodegradability and Renal Clearance
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초록
내용
Computed Tomography (CT) is a widely used imaging technique for ischemic stroke with high penetration depth, fine resolution, and short operation time. While conventional molecular CT contrast agents can locate the blocked blood vessel, it is impossible to know the exact size and shape of the clot. Nanoparticle-based contrast agents are possible to express the size and shape. However, accumulated nanoparticles at organ may have toxicity. Therefore, we suggest the polymeric nanoparticle as biodegradable CT contrast agent. A water-soluble iodinated monomer was used with a biodegradable linker for renal clearance. Imaging was successful showing not only the location but size and shape of the clot as well, even for a partially blocked blood vessel. In conclusion, we expect the polymeric nanoparticles work as biodegradable CT contrast agents capable of imaging the clot with exact size and shape.