Molecularly Imprinted Conducting Polymer Film Based on Extended-Gate Field-Effect Transistor for Selective Phenytoin Detection
발표자
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초록
내용
Phenytoin is known to be one of the most commonly prescribed anticonvulsants for the treatment of epilepsy. A continuous therapeutic monitoring is required to ensure effective treatment without toxicity in therapeutic concentration range from 10 to 20 μg/mL. Up to now, molecular imprinted polymers(MIPs)-based sensing systems have been reported to determine the phenytoin due to their numerous advantages such as simple preparation, high reliability, and stability. In particular, molecularly imprinted conducting polymers(MICP)-based electrochemical sensors have great potential in detecting a target molecule because it can identify the minute changes in potential on the surface of MICP sensor. In this study, we introduce a MICP-based electrochemical sensor with catechol derivatives for detecting phenytoin using an extended-gate field-effect transistor (EG-FET).