Engineering Strategies to Modulate the Gut Microbiome and Immune System
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We present new biomaterial-based strategies for altering the gut microbiome and amplifying anti-tumor immune responses in a safe and effective manner. We are developing new dietary fiber-based biomaterials for in situ modulation of the gut microbiome for augmenting local and systemic immune responses. We will present the therapeutic potential of our gut modulation approach in the context of improving the safety and efficacy of immune checkpoint blockers. In addition, we will present a new nanoparticle platform for systemic delivery of STING (stimulator of IFN genes) agonists with potent efficacy, favorable pharmaceutical properties, and acceptable safety profiles. Our biomaterial-based strategies may offer powerful and convenient approaches to regulate the immune system as potential therapies for cancer and other diseases.