Tannic acid-cisplatin Complex Mediated Self-Assembly of Nanogel Structure with Pyrene-Modified Chitosan for Enhanced Anticancer Efficacy and Colloidal Stability
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We present the synthesis of pyrene-modified chitosan (Py-CS) nanogels through the hydrophobic interactions and excimer formation of pyrene anchors in aqueous solutions. Tannic acid (TA) was further added to the Py-CS solution as a colloidal stability-enhancing additive by noncovalent secondary interactions such as π-π stacking and hydrogen bonding, which can be observed with fluorescence and FT-IR spectroscopy. Subsequently, solution viscosity of the resulting nanogels was analyzed to evaluate the nanoscale behavior of the modified polysaccharides. Also, TA reported as a substance that prevents tumor cell growth is evaluated to have a high anticancer effect if combined with cisplatin, an inorganic anticancer agent, especially in liver cancer cells. In this study, chitosan-based nanogels adsorbed with cisplatin-tannic acid complex (Py-CS/TA-PtII) are proposed as drug delivery systems with enhanced anticancer effects.