GAL-1 protein presenting natural supported lipid bilayer coating of blood-interfacing devices for GAL-1 related multifunction
발표자
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초록
내용
Local cell injury and inflammation in implantation sites lead to subsequent serious complications still unresolved challenge of various medical devices with blood-contacting applications. In this study, inspired by the role of galectin-1(GAL-1) in inflammatory and immunomodulatory processes, we constructed a multifunctional surface with GAL-1 protein-rich natural supported lipid bilayer coating to enhance antifouling properties, promote endothelial cell activity and anti-inflammatory effects. The constructed surface showed the expected antifouling activity by resisting the adhesion of proteins, platelet, and bacteria. Notably, the surface gal-1 protein shows the ability to promote endothelial function and inhibit smooth muscle cell proliferation. In addition, the GAL-1 presenting surface reduced smooth muscle cell and macrophage-released inflammatory cytokines. This study demonstrated multifunctional surfaces with efficient and straightforward construction for blood-contacting devices.