MXene-based biosensor with PEDOT:PSS for EIS-based cortisol concentration detection
발표자
()
초록
내용
Cortisol which is known as a stress hormone should be controlled and measured condignly. In this research, cortisol biosensing electrode including PEDOT:PSS/MXene was fabricated. Metallic MXene shows outstanding electrical conductivity and biocompatibility has been attracted attention as a one of next generation of 2D material. PEDOT:PSS was brought to develop electrostatic interaction and in order to attach MXene into substrate. In order to attach antibody to MXene, functional groups of MXene should be modified. Hydroxy group, one of functional group of MXene, can be reacted with carboxyl group in oxalic acid. Then, unreacted carboxyl groups on modified MXene(m-MXene) can be reacted with amino groups forming amide bonding through EDC chemistry. Finally, passivation with BSA to prevent non-specific binding was implemented. EIS indicates outstanding performance in selectivity and sensitivity. This research suggests that MXene could be employed as a new type of biosensing platform.