Polysaccharide Derivative-based Multifunctional Coating of Intravascular Catheters: A Simple and Biocompatible Method to Improve Antimicrobial and Antithrombotic Activities
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초록
내용
Antimicrobial, antithrombotic activity and low-friction properties are indispensable for the surface of intravascular catheters (ICs). In this study, we proposed a strategy that fabrication of multifunctional ICs by eco-friendly and biocompatible modification method. IC was coated with multifunctional polysaccharide, O-carboxymethyl chitosan (O-CMC). O-CMC coating layer was adapted to be porous (micro- and nanoscale), creating superhydrophilic property. Especially, the superhydrophilic surface exhibited outstanding anti-adhesion performance of Escherichia coli and platelet. Anti-adhesion performance could be synergistic effect along with intrinsic antimicrobial and antithrombotic properties of O-CMC. Furthermore, we verified the low-friction property of porous O-CMC coated IC via measurement of coefficient of friction under continuous wet friction conditions. We further demonstrated the excellent trackability of actual IC that applied proposed coating strategy.