Thermo-sensitive injectable hydrogel for localized drug delivery of cancer
발표자
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초록
내용
Injectable hydrogels are one of the biomedical materials that keep the fluid state out of the body and transform into gels after injection into the body. Injectable hydrogels usually need external stimuli such as temperature or pH to trigger the sol-gel phase transition. NIPAAm which is thermo-sensitive material having LCST at ~32 degrees has been attracting attention in many injectable hydrogel fields. Although NIPAAm-based hydrogel has the advantage of phase transition at low LCST, acrylic acid (AAc) was employed to synthesize injectable hydrogels in order to improve biocompatibility and injectability. In this study, we prepared injectable hydrogel composed of PNIPAAm, AAc, and cross-linker. In addition, mechanical properties, drug release tests at 25 ℃ and 37 ℃, and cell viability were investigated.