Luminescent Particles with Controlled Afterglow for Photochemical Tissue Bonding
발표자
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초록
내용
Persistent luminescent particles (PLPs) have been widely used in a variety of fields owing to their capability of storing excitation energy and emitting long-lasting phosphorescence. However, poor afterglow performance and low biocompatibility of PLPs limit their applications in biomedicine. Here, we developed ZnS:Ag,Co particles for efficiently repeatable photochemical tissue bonding (PCB). ZnS:Ag,Co particles were synthesized and optimized through solid state reaction, which demonstrated much stronger intensity and longer lifetime of persistent luminescence than conventional PLPs. ZnS:Ag,Co particles were recharged rapidly with UV light and emit visible green light, which activates hyaluronate-rose bengal (HA-RB) to induce radicals for crosslinking of dissected collagen matrix. An in vitro collagen fibrillogenesis analysis and an ex vivo tensile strength test of incised skin tissues confirmed the efficient tissue regeneration effect of ZnS:Ag,Co particles.