Organic electronic devices provide promising keys for in vivo electrophysiological recordings of neural system owing to their mechanical flexibility and biocompatibility. In Particularly, Organic electrochemical transistors (OECTs) have shown higher signal-to-noise ratio (SNR) due to local signal amplification obtained by super capacity (SC) of their organic active materials. Accessing the complex signal landscape over the whole brain or organ surface area of larger mammals will require matrix circuit in order to achieve the necessary spatio-temporal resolutions. With the high conformability and mechanical stability, we demonstrated to record various bio-medical signals with spatio-temporal information. Also, each conformable biomedical sensors has designed to have transparency, stretch-ability, blood compatibility to deal with different environment of target application.