Nuclear Magnetic Resonance Sequencing of Enantiopure Oligoesters Synthesized by Flow Chemistry
발표자
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초록
내용
A sequence-defined oligomer can be used to solve the lack of storage capacity to store increasing data. Here, we report synthesis of a library of sequence-defined oligomers of enantiopure α-hydroxy acids, oligo(L-mandelic-co-D-phenyllactic acid)s (oMPs) and oligo(L-lactic-co-glycolic acid)s (oLGs) by semi-automated flow chemistry. Due to the effect of the hydroxyl terminus having TBDMS protective group, the carboxyl terminus having allyl protective group, and the relative position of monomer in oligoester backbone, it was decoded by using 13C nuclear magnetic resonance (13C NMR). Finally, we were able to successfully encode and decode a bitmap image (192 bits) using a library of 12 equimolar mixtures of an 8-bit-storing oMP and oLG as the molecular media for archival information storage.