Development of GBR Membrane for Simultaneous Reconstruction of Bone and Epithelium
발표자
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초록
내용
Recent studies related with GBR membrane have focused on exclusion of rapidly growing non-osteogenic cells into the bone defect for effective bone regeneration. Although it is well-established that the GBR membrane can accelerate new bone formation, a high risk of infection caused by loosening between membrane and epithelium remains as a clinical challenge. Many surgeons continue to raise the need for development of GBR membrane which can induce simultaneous reconstruction of bone & epithelium. In this study, we developed a film with leaf-stacked structure (FLSS) on both faces. It was expected that the FLSS allow sustained release of BMP-2 and PDGF-BB from each surface, and thus achieve effective regeneration of bone (by BMP-2) and epithelium (by PDGF-BB) on both sides, respectively. The morphology, physical properties, growth factor release pattern and cell behavior (adhesive/migration/differentiation) of growth factors-loaded FLSS were investigated.