Development of Low Modulus PMMA-based Bone Cement to Reduce Adjacent Vertebral Fractures after Vertebroplasty
발표자
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초록
내용
Vertebroplasty is commonly used technique to treat osteoporotic vertebral compression fractures. In this method, bone cement is injected into the vertebral body that has cracked or broken. Although the vertebroplasty using PMMA-based bone cement has been adapted in clinical practices as a gold standard to treat vertebral fracture, adjacent vertebral fractures caused by high modulus of injected bone cement is remained as a challenge of orthopedic surgeons. To solve the limitation of vertebroplasty using PMMA bone cement, we developed a PMMA bone cement containing PDMS (i.e., Sylgard) as a plasticizer to reduce modulus. The PMMA/Sylgard mixture was prepared by simple mixing and Sylgard in the bone cement was rapidly solidified by exothermic heat during PMMA curing. The SEM-EDS mapping, XRF analysis, mechanical property, injectability and cytotoxicity of PMMA/Sylgard mixture were investigated. And biomechanical test using osteoporotic porcine bone was also conducted.