Characterization of blood plasma-adsorbed porous film as a Hemostatic Agent
발표자
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초록
내용
Bleeding is one of the major causes of death in trauma patients. It is known that death occurs when the amount of bleeding exceeds 40% of the total blood volume. To prevent excessive life-threatening bleeding, various hemostatic agents have been developed. Recently, many hemostatic agents based on polymeric biomaterials are commonly adapted in clinical fields to manage bleeding. Platelet-rich plasma (PRP) containing a lot of blood clotting factors is also considered as a hemostatic agent. We expected that if the PRP can be adsorbed on surface with large surface area, it will maximize their hemostatic effect. Therefore, the main aim of this study was to develop a PRP-adsorbed porous film with leaf-stacked structure (PRP-FLSS) and to confirm the feasibility of the film as a hemostatic agent. The morphology, cytotoxicity, hemolysis analysis, blood coagulation (in vitro); prevention of hemorrhage, and histological evaluation (in vivo) of PRP-FLSS were investigated.