Biodegradable Vascular Scaffold for Augmented Re-endothelialization and Anti-inflammation Prepared by Coating of Modified Magnesium Hydroxide
발표자
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초록
내용
The most commonly used biodegradable polymer in BVS is poly(L-lactic acid) (PLLA), which has high biocompatibility and biodegradability. However, the implantation of BVS leads to restenosis and non-infectious inflammatory reactions in the body by of PLLA. Magnesium hydroxide (MH) can prevent inflammatory reactions by pH neutralization of acidic byproducts and everolimus (EVL) is well known as a drug for restraining stenosis. In this study, we fabricated the oligo-D,L-lactic acid grafted MH (GFMH) and EVL coated BVS. The GFMH and EVL coated BVS indicated high biocompatibility and low inflammatory reaction on endothelial cell (EC) and also it inhibited of smooth muscle cell (SMC) proliferation compared to control stent for in vitro. Moreover, in in vivo large porcine model, the abluminal coated BVS showed reendothelialization, antiinflammation, and antithrombotic effects. In conclusion, it suggests that the functional BVS can provide an effective way for cardiovascular disease treatment.