Promotion of Osteogenesis and Angiogenesis Using PLGA/MH/bECM Scaffold Combined with Bioactive PDRN
발표자
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초록
내용
Poly(lactic-co-glycolic acid) (PLGA) is one of the most common biopolymers owing to its biodegradability for tissue regenerations. However, there are major clinical challenges that the byproducts of PLGA cause an acidic environment of implanted site. In this study, the PLGA (P) scaffold was combined with magnesium hydroxide (MH, M) and bone-extracellular matrix (bECM, E) to improve anti-inflammatory ability and osteoconductivity. Moreover, the bioactive polydeoxyribonucleotide (PDRN, P) was additionally incorporated. This PMEP scaffold has osteogenic and angiogenic effects due to the PDRN, which interacts with the adenosine A2A receptor that upregulates expression of vascular endothelial growth factor (VEGF) and downregulates proinflammatory cytokines. The gene expressions related to osteogenesis and angiogenesis increased and the inflammatory factors decreased on the PMEP scaffold. In conclusion, it provides a promising strategy and clinical potential candidate for bone regeneration.