Effects of mechanical property of photo-crosslinked collagen hydrogels on fibroblasts
발표자
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초록
내용
Collagen, a natural polymer, has excellent biocompatibility and an easy fabrication method, and it is widely applied in biomedical. In this study, we manufactured a collagen-based cellular scaffold via photo-crosslinking with riboflavin phosphate and blue light. The physically crosslinked hydrogel without photo-crosslinking is the control group. The storage and loss moduli of photo-crosslinked hydrogels were measured to evaluate the mechanical properties. The stiffness of the cell microenvironment affects the cell behaviors, and they were measured through MTT assay, collagen, and GAGs quantification. The hydrogel stiffness can be designed depending on the purpose in the biomedical applications.