Gas precursor-loaded mesoporous-nanocomposite designed for enhanced photoacoustic signaling and sonodynamic therapy
발표자
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초록
내용
For its therapeutic potential and non-invasive, site-specific characteristics, sonodynamic therapy (SDT) is continuously being studied for the treatment of cancer. However, clinical application faces limitations such as modest reactive oxygen species (ROS) production and biocompatibility issues. To overcome these obstacles, we designed a polyethylene glycol-covered mesoporous silica-titania nanocomposite loaded with perfluorohexane (PFH@P-MSTN). PFH@P-MSTNs showed strong and prolonged photoacoustic (PA) signals compared with P-MSTNs, caused by radical vaporization of PFH. Also, when tumors were irradiated with ultrasound, mice injected with PFH@P-MSTNs had the highest levels of ROS due to enhanced cavitation by ultrasound and had significantly decreased tumor sizes. Consequently, considering the capacity of generating sufficient PA signals and ROS, PFH@P-MSTNs may exhibit remarkable potential for cancer diagnosis and treatment.