Multi-stimuli responsive hydrogels derived from hyaluronic acid for the controlled release of doxorubicin for cancer therapy.
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초록
내용
In this study, multi-stimuli responsive hydrogels based on hyaluronic acid were prepared for the controlled release of doxorubicin (DOX). Hydrogels were rapidly formed via a reverse electron demand Diels-Alder click chemistry by using a norbornene functionalized hyaluronic acid and a tetrazine cross-linker containing diselenide bonds. In a parallel experiment, indocyanine green (ICG) was encapsulated into hydrogels along with the DOX. The DOX-ICG-loaded hydrogels showed a sustained release of DOX after NIR exposure. The cytotoxicity experiments with human embryonic kidney cells showed that HA-Nb, crosslinker, and the formulated hydrogels were highly biocompatible (＞90% cell viability). The in vitro anti-tumor assessment experiment demonstrated that DOX-loaded hydrogels induced similar anti-tumor effect as compared to that of the free-DOX. Furthermore, DOX+ICG loaded hydrogels increased the efficacy of DOX after NIR treatment owing to the combine anti-tumor and photothermal effect.