Controlled delivery of chemically immobilized epidermal growth factor from injectable hyaluronic acid hydrogel
발표자
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초록
내용
Various biomaterials are being studied to deliver growth factors and drugs. However, it seems difficult to control the contents release rate. To control release, we modified acrylate group on the epidermal growth factor(EGF) that directly help wound healing. At the same time, acrylate modification containing polyethyleneglycol(PEG) was performed to investigate the release degree according to the molecular legth. In the case of hydrogel, injectable gel was prepared, and it was using methacrylated hyaluronic acid(HA-MA) and thiolated hyaluronic acid(HA-SH). Blue light was irradiated, modified EGF and HA-SH were conjugated and HA-MA and HA-SH were cross-linked by thiol-ene reaction, respectively. Successful modification and gel fabrication were confirmed through MALDI-TOF and FT-IR. The release of the modified EGF conjugated inside the gel was confirmed through gel degradation and ELISA. As a result, it was confirmed that the release continued for longer period than the unmodified EGF.