Lipid-modified amphiphilic DNAs for delivery of biological molecules
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This presentation will focus on synthetic lipid-DNAs that have hydrophobic alkyl segments covalently connected to nucleobase. These materials exhibit both the counterbase-recognition of DNA and the aggregation behavior of amphiphilic macromolecules. We believe that the self-assembled lipid-DNA micelle is a versatile delivery platform, where biomolecules such as DNA, RNA and peptide are loaded within the carrirer for anti-cancer therapeutics or elsewhere. Here, successful in vivo utilization of the materials in immunology and gene silencing will be demonstrated. We also investigated molecular dynamics of the lipid-DNAs by computational methods.