Ion-Selective Artificial Membrane-Incorporated Hydrogel Ionic Transistor for Real-Time K<SUP>+</SUP> Signal Monitoring
발표자
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초록
내용
Toward next-generation high-performance biosensors, target-selective signal amplification capability must be fulfilled, which can be achieved by introducing molecular filtration membranes. Typical physical filters cannot guarantee the target selectivity in body fluids because many other molecules of similar size cannot be distinguished. To solve this problem, we aimed to rely on molecular recognition, and in this work, we newly developed a biological membrane-inspired K+-selective membrane as a model system. We created artificial K+ channels by hydrophobically modifying G-quadruplexes that contain K+ binding motifs. Through the channel-embedded membrane, anion transport was perfectly blocked, and K+-preferred ion transport among similar-sized alkali metal ions was accomplished. When the K+-selective membrane was introduced to the hydrogel ionic transistor, a novel K+ real-time monitoring sensor was successfully fabricated which can also detect K+ signal changes even in body fluids.