Newly synthesized pH-sensitive degradable polymer for gene delivery targeting angiogenic effect in ischemia disease
발표자
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초록
내용
Human adipose-derived stem cells (hADSCs) transplanted to ischemic wounds have shown promising therapeutic effect. However, clinic effect of hADSCs transplantation is low due to the poor engraftment and reduced viability of the cells. Herein, we have suggested pH-sensitive degradable polymer micelles based on poly(ethylene glycol)-poly(amino ketal) for efficient angiogenic gene delivery to hADSCs for improving therapeutic effect. Through our newly synthesized polymer micelles, hADSCs showed significant improvement in angiogenesis when transplanted to ischemic lesions compared to conventional method of gene transfection.