Heterogeneous Integration of Soft Silicon Electronics with 2D Materials for Bioresorbable Neurochemical System
발표자
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초록
내용
Although neurotransmitters are key substances closely related to evaluate degenerative brain diseases as well as regulate essential functions in the body, many research efforts have been focused on monitoring relatively associated physical, mechanical and electrophysiological parameters, rather than direct observation of such biochemical messengers. Here, we introduce a soft, bioresorbable silicon-based neurochemical analyzer incorporated with two-dimensional transition metal dichalcogenides as a completely implantable brain-hacking system that can collect time-dynamic behaviors of dopamine and relevant parameters in peripheral regions at the same time. Systematic characterizations demonstrate reversible, stable and long-term operational performances of the degradable bioelectronics with excellent sensitivity and selectivity. A complete set of in vivo experiments illustrates capabilities for a potential use as a clinically accessible tool to associated neurodegenerative diseases.