Synthesis of thiolated-Poly Ethylene Glycol via Post-modification polymerization
발표자
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초록
내용
Poly(ethylene glycol) (PEG) is a hydrophilic polymer, commonly used in batteries, medicine, pharmacy, and various industry. To increase its performance, the synthesis of functionalized PEG has been of interest. Usually, functionalized-PEG is synthesized from epoxide monomers. However, the scope of monomers is limited due to functional group incompatibility and uneven reactivity. To overcome these limitations, the synthesis of functionalized-PEG via post-modification polymerization is pursued. Using the C-H functionalization strategy, PEG was directly functionalized. The reactive radical intermediate was captured by disulfide, producing the corresponding thiolated-PEG without decreasing the molecular weight. The reaction development and scope of our development will be discussed.