Study on anti-thrombotic properties using zwitterionic and tetra-fluorinated polyurethane-based surface-modifying oligomers
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To prevent the anti-thrombosis and the bacterial biofilm formation, zwitterionic or fluorinated macromolecules have been proposed as a surface-modifying oligomer (SMO) for the surface modification of polymeric biomaterials. In this study, novel oligomers with zwitterionic and tetra-fluorinated polyurethane backbones (ZFPU) were synthesized and blended with polyvinyl chloride (PVC) to evaluate anti-fouling and anti-thrombotic effects. 1H NMR and FT-IR have demonstrated that zwitterionic groups and tetra-fluorinated segments were successfully introduced to the ZFPU backbone. We also investigated the protein adsorption, platelet adhesion and the wettability of ZFPU/PVC films. These results demonstrated that the surface of ZFPUs-blended PVC significantly suppresses the protein adsorption and the platelet adhesion/activation compared to those of the pristine PVC. It is expected that our novel SMOs will have high hope for blood-contacting medical devices.