Zwitterionic surface-modifying oligomers for conventional biomedical polymers
발표자
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초록
내용
Although polyvinyl chloride (PVC) has been extensively used for implantable medical devices, some huddles such as thrombosis and infection have been consistently being controversial. Zwitterionic groups have been immersed as promising functional groups for non-fouling materials preventing the above-mentioned problems. In this study, we designed a novel series of zwitterionic surface-modifying oligomers with polyurethane backbone (zPUs) to give anti-thrombogenic and anti-microbial properties to PVC. The blends of PVC and synthesized zPUs were prepared through a hot melting process. The protein adsorption test using fibrinogen and albumin demonstrated the improved protein-resistant effect as the amount increases. Moreover, zPU-blended PVC suppressed the adhesion and activation of platelets on the surface. Therefore, the zPU series can be useful as an anti-fouling additive for various PVC-based materials in biomedical applications.