Influence of polymer and metal ion on drowning out crystallization process of Quercetin
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Crystallization is widely used in various industries such as pharmaceutical, food and material industries. If there is another material mixed with target material during crystallization, crystallization process could be affected by it. A lot of researches show crystal’s polymorph change by polymer by creating mesocrystals. It is also known that polyphenols with hydroxyl group like tannic acid, has hydrogen bonding with polymer like polyvinylpyrrolidone (PVP) or polyethylene glycol (PEG) resulting in gelation. In this study, we investigated the effects of polymer – TA – metal ion (P-TA-M) composite’s effect during drowning out crystallization of quercetin. When composite is involved in crystallization, crystal structure become amorphous and average crystal size reduces to nano scale. The effect of polymer, tannic acid and metal ion composite on the surface of polyphenol crystal may increase the possibility to improve bioavailability of poorly soluble drug with hydrogen bonding.