Fabrication of stimuli-responsive nanofiber and nanoparticles via electrospinning/electrospray
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We demonstrate an electrospray/electrospinning process to fabricate stimuli-responsive nanofibers or particles that can be utilized as stimuli-responsive drug-loaded materials. A series of random copolymers consisting of hydrophobic ferrocene monomers and hydrophilic carboxyl groups was synthesized with free radical copolymerization. The morphologies of the resulting objects were electively varied from particulate to fibrous structures by control of the composition, suggesting that the morphology of electrosprayed/electrospun copolymer objects was governed by its composition highlighting the significance of the balance of hydrophilicity/hydrophobicity of the copolymer chain to the assembled structure. Resulting particles and nanofibers exhibited preserved responsiveness to reactive oxygen species during the deposition process, opening up the potential to fabricate ROS-sensitive material with various desirable structures toward different applications.