Multi-functional porous polysaccharide based coating for intravascular catheters
발표자
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초록
내용
Intravascular catheters are commonly used medical devices for patients in order to hemodynamic monitoring, medication administration, etc. Intravascular catheterization have several critical issues such as damage of blood vessel due to high friction, blood stream infection, blood coagulation. Herein, we attempted to functionalized the surface of catheter using O-carboxymethyl chitosan (CMC) which is a polysaccharide possessing lubricity, antimicrobial and anticoagulant activity. The hydrophobic catheter surface was modified with acrylic acid by electron beam induced grafting, leading to strong interfacial adhesion between grafted polyacrylic acid and CMC. The CMC coating layer was fabricated as a porous structure using Poly ethylene glycol. As a result, the coated surface exhibited superhydrophilicity under specific fabrication conditions. Furthermore, the effects of various pore system on the performance of functional coated catheter surface were discussed.