Wound-contractable thermo-responsive hydrogel for acceleration of wound healing process
발표자
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초록
내용
In embryonic wound healing, actin cables are assembled around the edge of the wound, applying contractile force to the center of the wound, makes perfect, scarless regeneration. Inspired by these findings, we developed body temperature shrinkable hydrogel dressing which made of thermo-responsive polymers, poly(NIPAM) and Tetronic 1307. These polymers were modified with tyramine (TA) for in situ enzyme-mediated hydrogel fabrication using HRP and H2O2 as enzyme and substrate. The gel maintained its stable form under LCST, while shrunk over LCST to generate contractile force which can be applied to wound site. Hydrogel’s thermo-responsive property, mechanical property, cytotoxicity, contractile force and wound contraction ability were characterized. In vitro studies demonstrated the therapeutic potential of hydrogel as advanced wound dressing.