Fabrication and application of azide PEG based clickable hydrogel
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초록
내용
Hydrogel is a unique material as swelling water polymer. Water swelling property is important to applicate at bio material. There are several way to use hydrogel with bio material including cell, DNA, and proteins. In order to introduce functionality to hydrogel, researchers swelled hydrogel with functionalized aqueous solution. However, these method doesn’t work with flow system and not easy to control active site. Herein, we synthesis PEG based hydrogel with ECH ring opening polymerization. After polymerization, the Cl function groups are transfer to N3 group via azidation. Fabricated hydrogel can swelled with water and react with alkyne group of other material. We used hydrogel to click reaction with Alkyne Green Fluorescence Protein (GFP) and alkyne FITC to confirm click reaction of hydrogel.