Injectable Hybrid Hydrogels with Versatile Properties for Various Biomedical Applications
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초록
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Gelatin hydrogels have been extensively used in pharmaceutical and medical applications due to biocompatibility and biodegradability. However, it is difficult to control the properties of natural polymer-based hydrogel without any modification. To overcome this, natural/synthetic hybrid hydrogels incorporating PEG into gelatin hydrogels could control their properties with biocompatibility. In this study, we prepared gelatin/PEG hybrid hydrogels depending on the lengths and contents of PEG, formed by enzyme-mediated crosslinking. The physicochemical of hydrogels were independently adjusted by PEG parameters with cyto-compatibility. Furthermore, the formulation with the highest physicochemical properties showed effective hemostasis and wound healing in vivo. In conclusion, the gelatin/PEG hybrid hydrogels with tunable physicochemical properties could be expected to be a promising biomaterial for various applications. Acknowledgement: NRF-2019R1A6A1A11051471 & 202012A01