Promoted Osteogenic Differentiation by MXene Nanosheets and Application to PLCL/Collagen Nanofibrous Matrices
발표자
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초록
내용
MXene, one of the most emerging two-dimensional (2D) nanomaterials, has drawn increasing attention due to its unique physicochemical properties. Herein, the osteogenic potential of MXene nanosheets was explored and then they were incorporated into electrospun poly(L-lactide-co-ε-caprolactone)/collagen (PLCL/Col) nanofiber matrices to further investigate their synergistic activity for bone tissue engineering (BTE) scaffolds. It was found that MXene nanosheets were not cytotoxic to MC3T3-E1 preosteoblasts at lower than 31.3 μg/mL and significantly promoted their ALP activity without hampering cell growth. PLCL/Col matrices were shown to provide favorable environments for cell attachment. In conclusion, it is suggested that the PLCL/Col nanofiber matrices with MXene nanosheets can be promising candidates as novel scaffolds for BTE.