Preparation of hydrogel adhesive with high mechanical/adhesion properties and application for a drug delivery system
발표자
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초록
내용
Poly(acrylic acid) (PAA) hydrogel is widely used as biomedical materials due to their biocompatibility. However, hydrogel has disadvantages of low mechanical and adhesion properties. We fabricated a UV-curable hydrogel adhesive with high tack property, peel strength, and adhesive force by adding additives. Herein, the modified cellulose nanofiber (m-CNF) and silica nanoparticles (SNPs) were exploited as additives to increase the internal cohesion of hydrogel adhesive introducing physical bonding networks between the carboxymethyl group of m-CNF and the hydroxyl group of the SiO2 NPs in the hydrogel. Furthermore, cytotoxicity test and drug release test ascertained that hydrogel has an availability as a drug carrier. According to the results, it was expected that this hydrogel nanocomposites could be applied as transdermal drug delivery system.