Synthesis of core-shell structured upconversion nanoparticles for photodynamic cancer therapy
발표자
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초록
내용
Noninvasive and multi-functional sensitive drug nanocarrier has been intensively studied for cancer treatment and diagnosis. Recently, rare earth-doped upconversion nanoparticles (UCNPs) have been widely studied due to their unique energy level structures which can emit higher visible energy after absorbing lower near-infrared energy, high photostability, low autofluorescence background, and deep tissue penetration depth. In this study, we synthesized the UCNPs with a core-shell structure by thermal decomposition method. The surface modification of UCNPs was conducted for bioimaging and photodynamic therapy (PDT) applications. The size, size distribution, crystalline morphology, photoluminescence properties and PDT effects of the surface-modified UCNPs were also investigated.