T cell-mimicking nanoparticles for cancer immunotherapy
발표자
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초록
내용
Although cancer immunotherapy shows promising efficacy in cancer patients, a majority of the patients still do not respond to the therapies. Here we present that nanoparticles can modulate the immunity for cancer treatment. Nanoparticles decorated with T cell membrane and loaded with anticancer drug can target tumor and kill cancer cells in similar ways to T cells. In addition, the nanoparticles aid to maintain cytotoxic T cells’ anti-tumor immunity in immunosuppressive tumor microenvironment (TME). Indeed, the nanoparticles exhibited higher therapeutic efficacy than an immune checkpoint blockade in melanoma and lung cancer treatment in murine models. Meanwhile, tumor-associated macrophages (TAM) in TME have tumor-promoting phenotype. We designed nanoparticles that can reprogram TAM to induce phagocytosis of cancer cells and initiate anti-tumor immunity. Taken together, nanoparticle approaches may provide a new avenue to cancer immunotherapy.