Development of HA-PCL nanoparticles loaded with Upconversion dye for transdermal delivery
발표자
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초록
내용
In phototherapy, there are problems with biomedical applications when visible light is irradiated on the skin owing to low penetration into tissue. For these reasons, we developed polycaprolactone grafted hyaluronic acid nanoparticles (HA-PCL NPs) for transdermal delivery of upconversion (UC) dye which can convert light with low energy into high energy as light source with large penetration depth. The successful preparation of HA-PCL NPs containing UC dyes were confirmed by DLS and TEM, and stability was identified by the UV-Vis spectroscopy. In addition, the penetration test of NPs for 24 hours on porcine skin confirmed successful permeation by measuring variation of blue light intensity. Based on these results, our HA-PCL NPs are appropriated for transdermal delivery of UC dye and can resolve the limitation of low penetration due to short wavelengths for effective phototherapy and showed the potential as a phototherapy platform for treatment of various skin disease.