Photo-responsive Poly(N-isopropylacrylamide-co-acrylic acid)/Prussian blue Nanocomposite as a Potential Drug Delivery System
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Photo-responsive hydrogels are ideal candidates for applications in drug delivery systems due to their minimal invasiveness and potential for remote control. Therefore, many thermal-responsive hydrogels have been combined with photothermal agents (PTAs). In our work, Prussian blue (PB) was selected as a PTA and combined with thermal-responsive poly(N-isopropylacrylamide) based hydrogel to create photo-responsive hydrogel. PB was synthesized using polyvinylpyrrolidone (PVP) to improve water dispersibility. In sequence, PVP-stabilized PB nanoparticles were mixed and introduced to hydrogel (pNIPAAm-co-AAc@PB). When pNIPAAm-co-AAc@PB was irradiated with an 808 nm laser, PB absorbed the NIR light and converted it into heat. Then, the heat was transferred to pNIPAAm-co-AAc, which caused the lower critical solution temperature phase transition. As a result, the pNIPAAm-co-AAc@PB could release the drug by shrinking and able to apply as a potential drug delivery system in response to NIR light.