Simultaneous photothermal and photodynamic properties by conjugated polymer dots
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초록
내용
Photodynamic therapy (PDT) is based on a method of biochemical reactions to damage tumors mediated by a photosensitizer, which generates reactive oxygen species (ROS) under a light irradiation. Photothermal therapy (PTT) is a hyperthermia therapeutic approach for cancer that employs heat change by photothermal agents from irradiated light to burn cancer cells. To build the intricate treatment system for the synergies of the two treatments, it is usually necessary to individually combine the PTT and PDT agent into the nano-templates. However, two kinds of different wavelength lasers are needed to respectively activate PTT and PDT agents because of the absorption mismatch of these agents. To overcome this shortcoming, we synthesized a Prussian blue (PB)-based hybridized material that exhibited an enhanced photothermal effect by conjugated polymer dots under green light. The CPdots enhanced the photothermal effect of PB, as well as the generation of ROS and fluorescence imaging.