Light and temperature sensitive DPPC liposome with Hm-thiolated-CMC with gold nanoparticle and HmNIPAM
발표자
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초록
내용
Poly(N- isoproplacrylamide-co- hexyl methacrylate) (PNIPAM-HMA) which showed LCST behavior was insert into the dipalmitoylphosphatidylcholine (DPPC) liposome membrane. Besides, CMC was thiolated for better bonding to gold nanoparticles, with the addition of NIR, GNP would generate heat due to the surface plasmon resonance. Hydrophobic modification was for better insertion of CMC into the liposome membrane. DPPC itself had phase transition temperature, so it would respond to temperature changes, causing drug release if the temperature was higher than phase transition temperature(41℃). With the help of PNIPAM-HMA，the percentage of release degree increased. When under the NIR irradiation, liposome with GNP and PNIPAM-HMA release degree was higher than other ones. But because the GNP content was relatively small, so the release percentage was smaller than directly raising the external temperature.