Microbubble-Self-Aggregate Complex Used to Ultrasound-Mediated Enhanced Drug Delivery and Targeted Imaging
발표자
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초록
내용
Microbubbles can be applied to a bifunctional material; ultrasound contrast agent and drug delivery carrier. Microbubble delivers the drug by conjugation of drug delivery carriers seems like liposome or nanoparticles. Under the intensive ultrasound condition, the microbubble proceeds to collapse and release conjugated nanoparticles. When the microbubble is collapsed, strong mechanical stress can occur at the site of the blood vessel and increased permeability. It is called microjet. By using this technique, we can control drug release at the target area by the selective exposition of ultrasound. In this study, a self-assembled nanostructure, a loaded hydrophobic drug, was chemically conjugated to microbubble. The size distribution of microbubble and self-assembled nanostructure were analyzed by dynamic laser scattering(DLS). And the conjugation ratio of microbubble and micelle was examined by UV-Vis spectroscopy.